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How do Painkillers Work

Pain is the result of damaged cells in any area of the body. The human body makes two different types of cyclooxygenase enzymes, where COX-1 is responsible for protecting the stomach lining, and COX-2 causes inflammation.

The damaged cells excrete large amounts of an enzyme called cyclooxygenase-2. This stimulates the production of chemicals known as prostaglandins that are responsible for sending pain messages to the brain, which creates pain for the patient.

These chemicals also stimulate the release of fluid from the blood. This creates a cushion to protect the damaged cells from further damage, which causes swelling and inflammation on the surface of the patient’s skin.

Since there are different types of pain pills, they all work in different ways to prevent the message of pain from being interpreted. NSAIDs are non-specific, which means that they can affect both these chemicals.

They work in the body by inhibiting the production of COX-2, which in turn prevents the excretion of prostaglandins. This reduces pain and inflammation. Although the damaged cells are still present, patients will not feel the pain.

Opioid analgesics work by joining to opioid receptors in the brain, which prevents the signal of pain from being interpreted at all. Anti-depressants and anticonvulsants affect advancing of the chemical, GABA, which plays a role in pain control.

How Long do Pain pills Take to Work?

Different pain pills take various activation times to work in the body. This is attributed to the medication’s active ingredients and general pharmacology and structure. The various forms that pain pain meds are available in, also play a role in the time it takes to work.

Generally, it takes 20 to 30 minutes to see notable effects after taking analgesics. They will usually reach their peak concentration in one hour. These are normally immediate-release pills. The long-acting preparation pain pills release active ingredients slowly, generally over a timeframe of 12 hours. This provides a long-lasting period of pain relief.

Longer-acting or slow release analgesics are considered ideal for patients with chronic conditions. This is of-course due to the pills’ characteristic of providing a longer duration of pain control. Most often, opioid pain meds such as tramadol pills are available in this form as well as fast-acting / immediate release pills. Another commonly available medication for treating chronic nerve pain is hydrocodone.

Pain meds such as anti-depressants and anticonvulsants require a few days to a week or two, before showing their full effects after commencement. However, if a medication does not offer any noteworthy relief within two to three weeks, patients should consider another option. 

Can I Take Pain Pills?

Pain pills should only be administered when the patient has unbearable pain. It is not advised to take pain meds of any type for no valid reason, as this may cause unnecessary side effects. Since there are many analgesic medication types and strengths, patients should read their medication leaflets to note any interactions or contraindications.

Anyone over a certain age can use over-the-counter pain meds, unless they are allergic to a specific ingredient in the pharmaceutical. Patients with an affinity for misuse, kidney or liver problems and alcohol dependence should visit their doctor before taking any pain meds.

More potent analgesics have much more interactions and contraindications, as their composition and effects are more prominent in the body. Understanding a medication’s history and prior health conditions are significant in preventing prescription errors and risks. This information is also useful in deducing the possible reasons for the pain and the correct way to approach it, in terms of addressing underlying issues. 

Can I Mix Pain pills and Alcohol?

Patients often have the misconception that alcohol is an effective ‘pain meds’. However, this is a fallacy. The use of alcohol, in fact, has the potential to make the pain more severe than it already is. Although it does not directly provide pain relief, the inebriation of liquor causes the CNS to be temporarily dulled, so pain sensations are thus interpreted less intensely.

This is why mixing analgesics while having alcohol is a common, albeit misguided, practice. The risk of this combination depends on the classification of the particular medication being taken. However, combining any pain relief pills with alcohol is not recommended.

Even mixing alcohol with over-the-counter pain pills could potentially yield dangerous risks or side effects, such as extreme drowsiness or kidney and liver problems. Patients are at greater risks if they combine prescription pain meds with alcohol as the effects can be more debilitating.

Patients who take prescribed opioid analgesics for pain management are usually at risk of dependency and this risk is heightened further when alcohol is used in conjunction with these pain meds. A patient’s health can rapidly decline with continued use of the combination, and the tolerance can exacerbate unwanted effects.

The use of alcohol and prescription pain meds can pose the following risks:

  • ✔ Respiratory depression, which leads to a low level of oxygen in the blood.
  • ✔ Damage of the heart, brain and pancreas.
  • ✔ Abnormal behaviours such as distorted thoughts.
  • ✔ Loss of conscious, extreme drowsiness.

Certain prescription pain meds can, however, be safely combined with paracetamol. Nevertheless, this can increase the possibility of liver damage, when combined additionally with alcohol consumption. Due to these dangers, it is strongly advised never to mix any analgesic with alcohol. 

Are Pain pills Safe During Pregnancy

The feeling of pain and discomfort goes hand-in-hand with pregnancy. However, most women hesitate to use pain meds for pain relief. They often do not know what analgesics are safe for them and their babies. Luckily, there are safe pain pills on the market, but careful timing and caution is still necessary when using these pain meds for optimum results.

Adequate rest and a cold compress can assist with muscle pain and headaches during pregnancy, but if additional relief is needed, doctors usually recommend the use of paracetamol. By following the exact dosage, pregnant women can treat their pain without harming their baby.

Other pain relievers such as naproxen and ibuprofen should be avoided as they have been associated with a decrease in amniotic fluid levels. This puts more pressure on the umbilical cord, which is the lifeline of the baby.

The use of opioid pain pills should be avoided entirely during pregnancy. Opioids can cause a condition called neonatal abstinence syndrome (NAS), which is where a baby has withdrawal symptoms from the presence of opioids. This can be distressing for both mother and child. For the treatment of chronic pain conditions, it is important to seek medical advice for the safe use of prescription pain meds.

For more information on how to buy pain meds online, the customer service team at online pharmacy is available to help 24-hours.

More Product Information:

  1. Painkiller Side Effects
  2. Which Painkiller is the Best?
  3. Types of Painkillers
  4. What are Painkillers?

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Updated by Admin: March 18, 2023

Cindy Walker – Apr 14, 2021
Hi Sarah I have read a number of your blogs but this is my first time to comment. Thanks to your blogs I have now been able to make an educated choice, treat my condition and get my life back on track. Many thanks Cindy Walker

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