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Which Painkiller is best?

When we think of the best pain meds, several names come to mind. This is because pain meds are structured and designed with unique identities that accommodate different pain types and levels. Thus, one specific solution cannot be chosen for all circumstances.

The choice of the ideal pain reliever often depends on various internal and external factors. The WHO analgesic ladder of medicines is an excellent tool, which often helps patients identify their pain and investigate possible treatment options.

Below is a summary of commonly used pain relievers:

Best Pain meds Options

Key points


Paracetamol can be administered to treat mild to moderate pain.

  • ✔ It acts primarily on the brain and affects how the user feels pain.
  • ✔ It has an exceptional safety profile and a versatile disposition that allows it to treat both acute and chronic pain.
  • ✔ It is ideally used when needed; however, it should be taken at regular intervals for chronic pain. 

Non-steroidal anti-inflammatories 

  • ✔ Ibuprofen
  • ✔ Diclofenac
  • ✔ Naproxen
  • ✔ Mefenamic acid 

NSAIDs are used to treat mild-to-moderate inflammation or swelling and pain 

  • ✔ They function by inhibiting and reducing hormones and enzymes that cause swelling and pain within the body.
  • ✔ NSAIDs can be administered for short-term pain resulting from injuries or due to flare-up.
  • ✔ NSAIDs may not be ideal for longer-term pain issues as they treat cases of inflammation, which are usually not the cause of chronic pain. 


Opioids can be administered to treat moderate-to-severe temporal pain that stems from various conditions or injuries. In certain situations, they can be used long term as well.

  • ✔ Codeine, tramadol and dihydrocodeine are typically prescribed for moderate pain, while oxycodone and morphine are administered for more extreme or severe pain levels.


Best Pain meds for Period Pain

Menstruation, commonly known as a period, is a monthly cycle of vaginal bleeding that occurs in all adolescent women. This bleeding is often accompanied by varying levels of pain called dysmenorrhea. This pain is sometimes unbearable, and women often look to pain medss to help alleviate their symptoms.

According to the ACOG (American College of Obstetricians and Gynaecologists), NSAID is the best pain meds option for menstrual cramps. Some studies even found that these drugs could decrease abnormally heavy flows or bleeding.

Anti-inflammatory pain meds are often used to relieve menstrual pain because they inhibit the production of prostaglandins. Prostaglandins are a group of compounds with varying-like effects, which include the promotion of uterine contractions.

By blocking the production of this compound, the tablet successfully reduces period pain. NSAIDs are also the safer option, as they are not processed through the liver like most period pain medicines – instead, they are metabolised by the kidney, which ultimately safeguards the liver.

Best Pain meds for Toothache

Toothaches are often unpredictable as they can sometimes suddenly appear with no prior warning signs. A toothache can physically affect the body, causing excruciating pain, alarming facial swelling, and flu-like symptoms. The best way to manage a toothache is to understand what causes it.

Over the years, dental experts have pinpointed the origin of toothaches to be internal swelling. The pulp (blood vessels, nerve and connective tissues) becomes too large for the tooth’s rigid and inflexible structure, leaving no space for expansion and pressure reduction. The key to getting rid of the pressure is to stop and reduce the inflammation with pain meds, which are specifically designed to do so.

The most appropriate OTC option would be ibuprofen or aspirin, while the best pain meds in the prescription category would be codeine or co-codamol. These options are most effective because they can reduce swelling while simultaneously providing pain relief. These medications also come in combined treatment options, which can be buy pain pills online from any reputable online pharmacy. 

Best Pain meds for Back Pain

Back pain is caused by several issues, from declining muscle mass or an injury to ailments like osteoarthritis. This type of pain is often lingering and can last a few weeks, months or even years. This means that it sits on the fence of acute and chronic pain. Due to this pain’s ‘indecisive’ nature, patients are urged to get relief as soon as possible.

Before patients choose the best pain meds for back pain, they must ensure that various factors of their pain and health are taken into consideration. The most common go-to treatment for back pain relief is NSAIDs. These pills are available OTC, however, patients who need higher doses require a prescription. NSAIDs can successfully reduce pain, swelling and inflammation in the muscles around damaged nerves, tissues, or joints causing the pain.
If patients find that this option is not providing sufficient relief, they might benefit from stronger treatment options like opioid analgesics. Opioids interact directly with brain receptors and the spinal cord to alter an individual’s perception of pain. This process ultimately reduces intense pain sensations. 

Best Pain meds for Headache

A headache is often described as mild to severe pressure experienced at the forehead’s temples extending down to the neck’s base. The unpleasant occurrence of a headache can leave a patient unable to function optimally; thus, treatment is vital. When headaches progress in severity, patients cannot treat them using traditional methods – this warrants the use of a good pain meds. The best pain meds for headaches includes both OTC and prescription medication options. 

  • ✔ Over-the-counter pain meds – Simple OTC medications are usually the first line of treatment for headaches. Medications such as aspirin, ibuprofen and naproxen, among others, can provide effective relief to patients suffering from mild headaches.
  • ✔ Prescription pain meds- To alleviate severe tension-based headaches and migraines, prescription analgesics like opioid-based treatments are prescribed. These medications provide rapid pain relief within the prescribed timeframes.

Patients who do not find adequate relief with these options are often prescribed a fixed-dose combination treatment option. This option includes a single opioid pain meds paired with an over-the-counter treatment. Both treatment options will be prescribed at a standard dose that must neither be increased nor decreased. These combinations produce a higher level of relief and are commonly recommended to patients who suffer from severe/debilitating headaches.

For more information on how to buy pain meds, the customer service team at Alexonlinepharmacy is available to help 24-hours.

More Product Information:

  1. Painkiller Side Effects
  2. How do Painkillers Work?
  3. Types of Painkillers
  4. What are Painkillers?

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Updated by Admin: March 18, 2023

Cindy Walker – Apr 14, 2021
Hi Sarah I have read a number of your blogs but this is my first time to comment. Thanks to your blogs I have now been able to make an educated choice, treat my condition and get my life back on track. Many thanks Cindy Walker

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